Targeting tumour hypoxia: shifting focus from oxygen supply to demand

Rangeland ecosystem services: shifting focus from supply to reconciling supply and demand

www.frontiersinecology.org © The Ecological Society of America T concept of ecosystem services – the benefits that society receives from ecosystems (Daily 1997) – has been the subject of considerable attention in recent years, but most studies to date have focused on the supply (Sala and Paruelo 1997; Havstad et al. 2007; Carpenter et al. 2009; Raudsepp-Hearne et al. 2010) and valuation (Costan...

Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand

Maternal hypoxia is associated with a decrease in left ventricular capillary density while cardiac performance is preserved, implying a mismatch between metabolism and diffusive exchange. We hypothesised this requires a switch in substrate metabolism to maximise efficiency of ATP production from limited oxygen availability. Rat pups from pregnant females exposed to hypoxia (FIO2=0.12) at days 1...

Shifting the Focus From What to Why

After 4 decades of research on infant behavior and development, the time has come to shift our focus from What infants do to Why they do it when they do-to move beyond the single-minded search for mechanism and to consider the larger question of funcrion. Infants ate not merely incomplete adults who simply get better with age, but they are different organisms altogether, perfectly adapted at ev...

From Supply Chains to Demand Networks

Abstract. A paradigm shift is taking place in logistics. The focus is changing from operational effectiveness to adaptation. Supply Chains will develop into networks that will adapt to consumer demand in almost real time. Time to market, capacity of adaptation and enrichment of customer experience seem to be the key elements of this new paradigm. In this environment emerging technologies like R...

Surgical Outcomes: Shifting the Focus From Measurement to Improvement.